Why is diclofenac enteric coated

Check your blood pressure regularly and tell your doctor if the results are high. This drug may rarely cause serious possibly fatal liver disease. Get medical help right away if you have any symptoms of liver damage, including:.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at Before taking diclofenac, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs such as ibuprofen, naproxen, celecoxib ; or if you have any other allergies.

This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of:. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications see also Drug Interactions section. Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have a change in the amount of urine.

Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. This drug may make you dizzy or drowsy. Alcohol or marijuana cannabis can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana cannabis.

This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking.

Consult your doctor or pharmacist for more information. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.

Before using this medication, women of childbearing age should talk with their doctor s about the benefits and risks such as miscarriage, trouble getting pregnant. Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. This drug passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.

Do not start, stop, or change the dosage of any medicines without your doctor's approval. This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding.

These drugs are similar to diclofenac and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke usually at dosages of milligrams a day , you should continue taking the aspirin unless your doctor instructs you otherwise.

Ask your doctor or pharmacist for more details. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call Consequently, tablets are unable to maintain their integrity in the stomach leading to gastric irritation and poor bioavailability.

Download: Cited By: 1. Authors: A. Almarzouki, K. Omar, M. BMC Pharmacol Toxicol. Guidance for the industry: dissolution testing of immediate release solid oral dosage forms. Rockville, MD, Guideline on the investigation of bioequivalence. London, Multisource generic pharmaceutical products: guidelines on registration requirements to establish interchangeability.

No: Review of diclofenac and evaluation of its place in therapy as a nonsteroidal antiinflammatory agent. Drug Intell Clin Pharm. Top 10 most used drugs in the Kingdom of Saudi Arabia — Saudi Pharm J. PubMed Article Google Scholar. Comparative evaluation of different brands of enteric-coated diclofenac sodium tablets. In vitro Evaluation of commercially available enteric coated tablet containing diclofenac sodium. Evaluation of pharmaceutical and chemical equivalence of selected brands of diclofenac sodium.

In vitro dissolution study and assay of diclofenac sodium from marketed solid dosage form in Bangladesh. J Bioanal Biomed. Comparative quality evaluation of six brands of enteric coated diclofenac sodium tablets marketed in Addis Ababa. Hussein R, Hammami MM. Fully validated diclofenac HPLC assay. Pharmacopeia online. Ninth Edition of The International Pharmacopoeia, published in Al-Gousous J, Langguth P.

Oral solid dosage form disintegration testing-the forgotten test. J Pharm Sci. Dissolution testing for generic drugs: an FDA perspective. AAPS J. Download references. Muhammad M. Hammami, Rajaa F. You can also search for this author in PubMed Google Scholar. MMH designed the study, performed data analysis, and wrote the manuscript. All authors agree to be accountable for all aspects of the work and approved the final version of the manuscript.

All authors read and approved the final manuscript. Correspondence to Muhammad M. The study did not involve human or animal subjects. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Label information of a reference and seven generic enteric-coated 50 mg diclofenac sodium tablet formulations available on the Saudi market.

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Hammami, M. Eight enteric-coated 50 mg diclofenac sodium tablet formulations marketed in Saudi Arabia: in vitro quality evaluation. BMC Res Notes 13, Download citation. Received : 22 July Accepted : 04 September Published : 14 September Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Research note Open Access Published: 14 September Eight enteric-coated 50 mg diclofenac sodium tablet formulations marketed in Saudi Arabia: in vitro quality evaluation Muhammad M. Abstract Objective To evaluate in vitro quality of enteric-coated 50 mg diclofenac sodium tablet formulations on Saudi market.

Introduction Quality generic drug products save money and improve accessibility to health care [ 1 ]. Quality control tests and calculations Weight variation test: 20 randomly-selected unites of each formulation were examined.